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Cartridges come in needle lengths from 0.3 to 2.0 millimeters, targeting different skin layers. Shorter needles (0.3-0.5 mm) are ideal for sensitive areas, while longer needles (1.5-2.0 mm) treat deeper issues like scars. Dr. Pen’s vertical needle movement minimizes pain and skin damage, making it gentler than derma rollers. Choose the right cartridge based on your skin type and concerns for effective, glowing results.